Hydrochloric Acid → 1-(2-naphthylmethyl)-1H-imidazol-5-ylacetic acid hydrochloride

HRID 1741469

Reaktionsgleichung

C[O:2][C:3](=[O:21])[CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=2)[CH:8]=[N:7][CH:6]=1.[ClH:22]>>[ClH:22].[CH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:19]=[CH:20][C:11]=1[CH2:10][N:9]1[C:5]([CH2:4][C:3]([OH:21])=[O:2])=[CH:6][N:7]=[CH:8]1

Komponenten

Edukt 2

HCID 313Hydrochloric Acid

HCID 538068662-[1-(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetic acid methyl ester

Produkt 1

HCID 702062051-(2-naphthylmethyl)-1H-imidazol-5-ylacetic acid hydrochloride

Reaktionsbedingungen

Temperatur: 55 °C

Versuchsvorschrift

2-[1-(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetic acid methyl ester (0.92 g, 3.28 mmol ) was dissolved in 2.5m hydrochloric acid (50 ml ) and heated at 55° C. for 3 h. After this time, the solution was evaporated in vacuo to give the title compound as a white solid.

Aufarbeitung

customAfter this time, the solution was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-7041c7e805564b55964f8967b3fb0f40
Quelldatensatz: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05972984

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