HCID 21834627, Verbindung → N-Methyl-gamma-phenylbenzenepropanamine

HRID 1741474Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1741474
[CH2:1]([N:8]([CH2:10][CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)C)C1C=CC=CC=1>CO.Cl.[OH-].[Pd+2].[OH-]>[CH3:1][NH:8][CH2:10][CH2:11][CH:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Komponenten

5

Edukt 1

HCID 21834627HCID 21834627, Verbindung

Produkt 1

HCID 119812N-Methyl-gamma-phenylbenzenepropanamine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9942167Palladium hydroxideKatalysatorHCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of N-benzyl-N-methyl-3,3-diphenylpropylamine (1.03 g, 3.27 mmol) in methanol (35 ml) and aq. HCl (0.27 ml, of a 12.1M aq. solution, 3.3 mmol) was purged with argon and palladium hydroxide (405 mg) added. The flask was evacuated and shaken under an atmosphere of hydrogen (50 psi) for 18 hrs. The hydrogen was replaced by argon and the catalyst removed by filtration. The filtrate was treated with aq. NaOH (100 ml of a 1 M solution) and extracted into Et2O. The organic extracts were dried (Na2SO4) and evaporated in vacuo to afford the title compound as an oil.

Aufarbeitung

  1. additionadded
  2. customThe flask was evacuated
  3. customthe catalyst removed by filtration
  4. additionThe filtrate was treated with aq. NaOH (100 ml of a 1 M solution) and
  5. extractionextracted into Et2O
  6. dry with materialThe organic extracts were dried (Na2SO4)
  7. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-56f98a93da624136bb962b957c13c93d
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05972984

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