Isobutylbenzene → 4'-Isobutylhexanophenone

HRID 1741816

Reaktionsgleichung

Reaktionsgleichung von HRID 1741816
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[CH2:13]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]>ClCCl>[CH2:13]([C:17]1[CH:22]=[CH:21][C:20]([C:5](=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 10870IsobutylbenzeneHCID 67340Hexanoyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 108790194'-Isobutylhexanophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a suspension of aluminum chloride (6.67 g) in dichloromethane (70 ml) was added hexanoyl chloride (7.0 ml) at 0° C. After the mixture was stirred at 0° C. for 15 minutes, isobutylbenzene (7.9 ml) was added to the mixture. The mixture was stirred at 0° C. for 30 minutes and poured into ice water. The organic layer was washed with water, aqueous sodium bicarbonate and brine. The solution was dried over magnesium sulfate and evaporated to give 4'-isobutylhexanophenone (10.52 g) as a colorless oil.

Aufarbeitung

  1. stirringThe mixture was stirred at 0° C. for 30 minutes
  2. washThe organic layer was washed with water, aqueous sodium bicarbonate and brine
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-af47f5de3b80488b99e32313671bce86
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05334716

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