Epichlorohydrin → 2-[(4-Benzoylphenoxy)methyl]oxirane

HRID 1742775

Reaktionsgleichung

Reaktionsgleichung von HRID 1742775
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:16]([CH:18]1[O:20][CH2:19]1)Cl.[OH-].[Na+]>>[CH2:16]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1)[CH:18]1[O:20][CH2:19]1

Komponenten

4

Edukt 3

HCID 7835EpichlorohydrinHCID 143474-HydroxybenzophenoneHCID 14798Sodium Hydroxide2×

Produkt 1

HCID 3528162-[(4-Benzoylphenoxy)methyl]oxiraneAusbeute 83 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

1 g of 4-hydroxy benzophenone and 4.668 g of epichlorohydrin (0.025 mol) were dissolved, 20.5 mg of sodium hydroxide was added, and the reaction system was heated to 100° C. and then cooled to 95° C. Furthermore 201.4 mg of sodium hydroxide was added, and additional heating and agitation was carried out for 3 hours. The system was cooled to the room temperature, and salt was removed by filtering. The obtained filtrate was condensed under reduced pressure condition, and purified according to the silica gel chromatography to obtain 1.0 g of solid state 4-glycidyloxy benzophenone (Yield: 83%).

Aufarbeitung

  1. temperaturecooled to 95° C
  2. temperatureadditional heating
  3. temperatureThe system was cooled to the room temperature, and salt
  4. customwas removed
  5. filtrationby filtering
  6. customcondensed under reduced pressure condition
  7. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-e85f38e65d7646519f71c006d78eed22
Quelldatensatz
uspto-grants-1994_08
Patentnummer
US05342610

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