Piperidine → 5-Nitro-2-(piperidin-1-yl)benzonitrile

HRID 1744495Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744495
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(O)C>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5])([O-:12])=[O:11]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 855042-Chloro-5-nitrobenzonitrile

Produkt 1

HCID 48111995-Nitro-2-(piperidin-1-yl)benzonitrileAusbeute 67,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Chloro-5-nitrobenzonitrile (20 g) and piperidine (9.34 g) were added to ethanol (100 ml) and the mixture was stirred at a refluxing temperature for 1 h. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the residue to allow crystallization. The crystals were recrystallized from hydrous ethanol to give 5-nitro-2-piperidinobenzonitrile (17 g), melting point 75° C.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the residue
  3. customcrystallization
  4. customThe crystals were recrystallized from hydrous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-7452868fd7284777b5f6b3c5e52dd31f
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07015218B1

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