Potassium Carbonate → 1-(4-Chlorophenyl)-N-[3-cyano-4-(4-thiomorpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamide

HRID 1744623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1744623
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([N:32]3[CH2:37][CH2:36][S:35][CH2:34][CH2:33]3)[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24].C(=O)([O-])[O-].[K+].[K+]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([N:26]4[CH2:31][CH2:30][CH:29]([N:32]5[CH2:33][CH2:34][S:35][CH2:36][CH2:37]5)[CH2:28][CH2:27]4)=[C:22]([C:23]#[N:24])[CH:25]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 222278795-Amino-2-(4-thiomorpholinopiperidin-1-yl)benzonitrile

Produkt 1

HCID 222280341-(4-Chlorophenyl)-N-[3-cyano-4-(4-thiomorpholinopiperidin-1-yl) phenyl]-5-methylpyrazole-4-carboxamideAusbeute 38 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.67 g) and 5-amino-2-(4-thiomorpholinopiperidin-1-yl)benzonitrile (0.8 g) were added to pyridine (10 ml) and the reaction was conducted for 1 h at room temperature. To the reaction mixture was added aqueous potassium carbonate solution and the precipitated crystals were recrystallized from hydrous dimethylformamide to give the title compound (0.52 g), melting point: 256° C./decomposition.

Aufarbeitung

  1. customthe precipitated crystals were recrystallized from hydrous dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-7cfd13453c384a9da8c44f4a68b64ba1
Quelldatensatz
uspto-grants-2006_03
Patentnummer
US07015218B1

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