HCID 25183073, Verbindung → 6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamide

HRID 1746664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1746664
[CH:1]1([N:7]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=3)=[O:15])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(Cl)Cl>[CH:1]1([N:7]([CH2:25][CH:26]2[CH2:28][CH2:27]2)[C:8]2[N:13]=[CH:12][N:11]=[C:10]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH:23]=[O:24])=[CH:19][CH:18]=3)=[O:15])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 25183073HCID 25183073, Verbindung2×

Produkt 1

HCID 594468466-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamideAusbeute 92,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 6-[cyclohexyl(cyclopropylmethyl)amino]-N-[4- (hydroxymethyl)phenyl]pyrimidine-4-carboxamide (Intermediate 23, 990 mg; 2.60 mmol) in DCM (100 ml) was treated with Mn02 (2262 mg; 26.0 mmol) and the reaction mixture was stirred at room temperature for 18 hours the mixture was filtered through celite and the solvent was removed under vacuum affording the title compound as a yellow solid (912 mg; 79%), which was used without further purification for the following steps.

Aufarbeitung

  1. filtrationwas filtered through celite
  2. customthe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b24a8eb51c43463eb33f66a65434fd6a
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150519B2

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