Hydrogen chloride-ethyl acetate → 2-(trimethylsilyl)ethyl (1RS,2SR)-2-aminocyclohexanecarboxylate

HRID 1747041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1747041
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[C:15]([O:17][CH2:18][CH2:19][Si:20]([CH3:23])([CH3:22])[CH3:21])=[O:16])=O)(C)(C)C.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[NH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[C:15]([O:17][CH2:18][CH2:19][Si:20]([CH3:23])([CH3:22])[CH3:21])=[O:16]

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 723034442-(trimethylsilyl)ethyl(1RS,2SR)-2-[(t-butoxycarbonyl)amino]cyclohexanecarboxylate

Produkt 1

HCID 723033142-(trimethylsilyl)ethyl (1RS,2SR)-2-aminocyclohexanecarboxylateAusbeute 115,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2.82 g of 2-(trimethylsilyl)ethyl(1RS,2SR)-2-[(t-butoxycarbonyl)amino]cyclohexanecarboxylate in 10 ml of ethyl acetate, were added 20 ml of 4 M hydrogen chloride/ethyl acetate under ice-cooling, followed by stirring at room temperature for 6 hours. The reaction solution was evaporated to obtain 2.30 g of 2-(trimethylsilyl)ethyl(1RS,2SR)-2-aminocyclohexanecarboxylate as a colorless amorphous substance.

Aufarbeitung

  1. temperaturecooling
  2. customThe reaction solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-831a21ee6be84c21978c4f045593fe2a
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150541B2

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