Hydrochloric Acid → HCID 89560341, Verbindung

Reaktionsgleichung

C([NH:8][C@@H:9]([C:18]([OH:20])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([I:17])[CH:12]=1)(OC(C)(C)C)=O.O1CCOCC1.[ClH:27]>>[ClH:27].[NH2:8][C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([I:17])[CH:12]=1)[C:18]([OH:20])=[O:19]

Komponenten

Edukt 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 46737391N-((1,1-Dimethylethoxy)carbonyl)-3-iodo-D-phenylalanine

Produkt 1

HCID 89560341HCID 89560341, Verbindung

Versuchsvorschrift

A solution of Boc-3-iodo-D-phenylalanine (5 g, 12.8 mmol, available from Matrix Scientific and 3BSC) in 4M HCl in dioxane (63.9 mL, 256 mmol) under argon was stirred at RT for 15 h. The resulting suspension was filtered, washed with Et2O and dried in vacuo to give the title compound as a white solid. LC-MS B: tR=0.42 min; [M+H]+=291.98.