Ethyl 1-(5-bromopyridin-2-yl)-5-methylpyrazole-4-carboxylate → 1-(5-Ethyl-6-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid
Reaktionsgleichung
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[CH:17]=[CH:16][C:15](I)=[C:14]([CH3:19])[N:13]=2)[C:10]=1[CH3:11])=[O:5])C.[CH2:20](OC(C1C=NN(C2C=CC(Br)=CN=2)C=1C)=O)[CH3:21]>>[CH2:20]([C:15]1[CH:16]=[CH:17][C:12]([N:9]2[C:10]([CH3:11])=[C:6]([C:4]([OH:3])=[O:5])[CH:7]=[N:8]2)=[N:13][C:14]=1[CH3:19])[CH3:21]Komponenten
3
Versuchsvorschrift
1-(5-Iodo-6-methylpyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester described n Reference Example 31 was used in place of 1-(5-bromopyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester in Reference Example 28, and reacted and treated in a similar manner to give the titled compound.
Aufarbeitung
- customreacted