Sodium Hydroxide → 2,2,N-Trimethyl-N-(4-oxocyclohexyl)propionamide

HRID 1748614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1748614
O1[C:5]2([CH2:10][CH2:9][CH:8]([N:11]([CH3:18])[C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[CH2:7][CH2:6]2)[O:4]CC1.[OH-].[Na+]>Cl>[CH3:14][C:13]([CH3:16])([CH3:15])[C:12]([N:11]([CH3:18])[CH:8]1[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]1)=[O:17]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 79111757N-(1,4-Dioxaspiro[4,5]dec-8-yl)-2,2,N-trimethylpropionamide

Produkt 1

HCID 791196402,2,N-Trimethyl-N-(4-oxocyclohexyl)propionamideAusbeute 70,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

To N-(1,4-dioxaspiro[4,5]dec-8-yl)-2,2,N-trimethylpropionamide (12.5 g) was added 6 N hydrochloric acid aqueous solution (50 ml), and stirred at room temperature for 1 hour. After completion of the reaction, 12 N aqueous solution of sodium hydroxide (25 ml) was added thereto, and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and then the solvent was evaporated. To the obtained residue was added diisopropyl ether, the insoluble matter was collected by filtration, and then dried to give the titled compound (7.25 g) as a white solid. MS (ESI) m/z: 212 (M+H)+.

Aufarbeitung

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. customthe solvent was evaporated
  5. additionTo the obtained residue was added diisopropyl ether
  6. filtrationthe insoluble matter was collected by filtration
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-46e9cf22ab3d4654993d995afa42fd7b
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150555B2

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