Trifluoroacetic acid → 6-fluoro-1-phenyl-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:7](=[O:21])[N:8](CC3C=CC(OC)=CC=3)[CH2:9][C:10]=2[N:11]=1.C(O)(C(F)(F)F)=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:7](=[O:21])[NH:8][CH2:9][C:10]=2[N:11]=1Komponenten
3
Versuchsvorschrift
6-Fluoro-3-(4-methoxy-benzyl)-1-phenyl-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one (300 mg, 0.83 mmol) was deprotected according to the method of General procedure 1 (TFA deprotection). The free base was isolated and purified by column chromatography (SiO2, eluted with petrol—EtOAc 0-100%) to afford 6-fluoro-1-phenyl-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-2-one (120 mg). MS: [M+H]+=244.
Aufarbeitung
- customThe free base was isolated