1-(cyclopropylmethyl)-N-methylpiperidine-4-amine → 2-(5-amino-4,6-diisopropylpyrimidine-2-yloxy)-N-(1-(cyclopropylmethyl)piperidine-4-yl)-N-methylacetamide

HRID 1749308

Reaktionsgleichung

Reaktionsgleichung von HRID 1749308
[NH2:1][C:2]1[C:3]([CH:18]([CH3:20])[CH3:19])=[N:4][C:5]([O:11][CH2:12][C:13]([O:15]CC)=O)=[N:6][C:7]=1[CH:8]([CH3:10])[CH3:9].[CH:21]1([CH2:24][N:25]2[CH2:30][CH2:29][CH:28]([NH:31][CH3:32])[CH2:27][CH2:26]2)[CH2:23][CH2:22]1>>[NH2:1][C:2]1[C:7]([CH:8]([CH3:9])[CH3:10])=[N:6][C:5]([O:11][CH2:12][C:13]([N:31]([CH:28]2[CH2:27][CH2:26][N:25]([CH2:24][CH:21]3[CH2:23][CH2:22]3)[CH2:30][CH2:29]2)[CH3:32])=[O:15])=[N:4][C:3]=1[CH:18]([CH3:19])[CH3:20]

Komponenten

3

Edukt 2

HCID 433149081-(cyclopropylmethyl)-N-methylpiperidine-4-amineHCID 59336100Ethyl 2-(5-amino-4,6-diisopropylpyrimidine-2-yloxy)acetate

Produkt 1

HCID 593361322-(5-amino-4,6-diisopropylpyrimidine-2-yloxy)-N-(1-(cyclopropylmethyl)piperidine-4-yl)-N-methylacetamide

Versuchsvorschrift

As in Example 11, a carboxylic acid derivative was synthesized from Compound 13. Then, the title compound was synthesized from the obtained carboxylic acid derivative and 1-(cyclopropylmethyl)-N-methylpiperidine-4-amine in the same manner as in Example 49.

Quellen und Nachweise

ORD-Eintrag
ord-e94ac01bdc9b42d4a8be54e60fb342d5
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156817B2

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