Trifluoroacetic acid → 3-(2-Aminoethyl)-5-chloropyridine 1-oxide

HRID 1749470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1749470
C(OC([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[N+:13]([O-:18])[CH:14]=[C:15]([Cl:17])[CH:16]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[N+:13]([O-:18])[CH:14]=[C:15]([Cl:17])[CH:16]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 1181621543-(2-((tert-Butoxycarbonyl)amino)ethyl)-5-chloropyridine 1-oxide

Produkt 1

HCID 1181621313-(2-Aminoethyl)-5-chloropyridine 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-(2-((tert-butoxycarbonyl)amino)ethyl)-5-chloropyridine 1-oxide (90 mg, crude) in DCM (3 mL) was added TFA (1.5 mL) at 0° C. The resulting reaction mixture was stirred at room temperature for 1.5 h. The reaction mixture was concentrated to afford the crude title product, which was used directly in the next step without further purification (80 mg, crude). MS (ESI) m/z 173.1 [M+H]+.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-dbeae91f70fa424f9520f5e46384c33f
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156798B2

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