Reaktionsgleichung
[ClH:1].[F:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:12][CH2:13][NH2:14])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.Cl.CS(C)=[O:18]>>[ClH:1].[NH2:14][CH2:13][CH2:12][CH:7]1[C:6]2[C:10](=[CH:11][C:3]([F:2])=[CH:4][CH:5]=2)[NH:9][C:8]1=[O:18]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
To a solution of 2-(6-fluoro-1H-indol-3-yl)ethanamine hydrochloride (500 mg, 2.3 mmol) in DMSO (0.8 mL) was added hydrochloric acid (36%, 1.3 g, 12.8 mmol). The resulting reaction mixture was stirred at 50° C. in a sealed tube for 6 h. After cooling to room temperature, the reaction mixture was filtered. The resulting cake was stirred in EtOH (5 mL). The mixture was filtered and dried to give the desired product (250 mg, 1.28 mmol, 47% yield) as a yellow solid. MS (ESI) m/z 195.1 [M+H]+.
Aufarbeitung
- customThe resulting reaction mixture
- temperatureAfter cooling to room temperature
- filtrationthe reaction mixture was filtered
- stirringThe resulting cake was stirred in EtOH (5 mL)
- filtrationThe mixture was filtered
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-02d7faa9def14b0a8852b78dc2eb5fce
- Quelldatensatz
- uspto-grants-2015_10
- Patentnummer
- US09156798B2
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