HCID 178520033, Verbindung → HCID 178520032, Verbindung

HRID 1749865

Reaktionsgleichung

Reaktionsgleichung von HRID 1749865
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH2:11][OH:12]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH:11]=[O:12]

Komponenten

4

Edukt 1

HCID 178520033HCID 178520033, Verbindung

Produkt 1

HCID 178520032HCID 178520032, VerbindungAusbeute 70,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of (5-fluoro-1H-indazol-3-yl)methanol (0.215 g, 1.29 mmol) in ethyl acetate (10 mL) was added with manganese dioxide (1.12 g, 12.9 mmol), and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, then the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 5-fluoro-1H-indazole-3-carbaldehyde (0.150 g, 70%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)

Quellen und Nachweise

ORD-Eintrag
ord-6d2bea766d1d4247a844bb381000f9b8
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156827B2

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