Iodine → HCID 178418276, Verbindung

HRID 1750

Reaktionsgleichung

Reaktionsgleichung von HRID 1750
[Mg:1].II.[Br:4]CCBr.Br[C:9]1[CH:14]=CC(OC)=[CH:11][CH:10]=1.[CH2:17]1[CH2:21][O:20][CH2:19][CH2:18]1>>[CH2:11]([Mg:1][Br:4])[C:10]1[CH:18]=[CH:17][C:21]([O:20][CH3:19])=[CH:14][CH:9]=1

Komponenten

6

Edukt 5

HCID 807IodineHCID 77304-BromoanisoleHCID 78391,2-DibromoethaneHCID 8028TetrahydrofuranHCID 5462224Magnesium

Produkt 1

HCID 178418276HCID 178418276, Verbindung

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.

Aufarbeitung

  1. temperatureat reflux for 15 min
  2. stirringstirring
  3. customAfter an exothermic reaction
  4. stirringstirring
  5. customwas accompanied by a rise in temperature to 35° C
  6. temperatureThe mixture was cooled to 20° C.
  7. temperaturewith cooling
  8. stirringStirring
  9. additionafter the addition

Quellen und Nachweise

ORD-Eintrag
ord-f12406699295447fa245b2a1d83d7703
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05726315

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