Hydrochloric Acid → (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride

HRID 1750184Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750184
C(OC(=O)[NH:7][C@H:8]([CH2:13][S:14](=[O:18])(=[O:17])[NH:15][CH3:16])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:16][NH:15][S:14]([CH2:13][C@@H:8]([NH2:7])[CH2:9][CH:10]([CH3:11])[CH3:12])(=[O:17])=[O:18]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86714402((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 86714400(S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochlorideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

105 mg of ((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester were dissolved in 2 ml of dioxane and reacted with 1.3 ml of 4M hydrochloric acid in dioxane at it for 16 h. The reaction was concentrated in vacuo and the resulting crude product was used without further purification. 60 mg (100%) of (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride were obtained.

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe resulting crude product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b74da5948bf1434dae962c804cfef3db
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156796B2

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