HCID 86706943, Verbindung → HCID 86706944, Verbindung

HRID 1750261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750261
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:15]3[C:14]([N:16]4[CH2:21][CH2:20][O:19][CH2:18][CH2:17]4)=[N:13][CH:12]=[N:11][C:10]=3[N:9]([CH2:22][O:23]CC[Si](C)(C)C)[CH:8]=2)[CH:4]=[N:3]1>FC(F)(F)C(O)=O>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:15]3[C:14]([N:16]4[CH2:17][CH2:18][O:19][CH2:20][CH2:21]4)=[N:13][CH:12]=[N:11][C:10]=3[N:9]([CH2:22][OH:23])[CH:8]=2)[CH:4]=[N:3]1

Komponenten

3

Edukt 1

HCID 86706943HCID 86706943, Verbindung

Produkt 1

HCID 86706944HCID 86706944, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholin-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine (C4) (200 mg, 0.48 mmol) in trifluoroacetic acid (5 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure to afford the product as a yellow oil, which was used for the next step without additional purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-022e2ad23e8d48fc98dd22808b7eaa06
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156845B2

Notizen zur Reaktion

Wird geladen…