5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one → 6-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

HRID 1750452Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750452
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22](O)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:25]1[C:34]2[CH2:33][CH2:32][NH:31][CH2:30][C:29]=2[CH:28]=[CH:27][C:26]1=[O:35]>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22]([N:31]3[CH2:32][CH2:33][C:34]4[NH:25][C:26](=[O:35])[CH:27]=[CH:28][C:29]=4[CH2:30]3)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:2])([CH3:4])[CH3:3]

Komponenten

3

Edukt 2

HCID 210711895,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-oneHCID 867212902-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid

Produkt 1

HCID 712507616-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

Versuchsvorschrift

Using 2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid and 5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Aufarbeitung

  1. customby reaction and purification in the same manner as in the method

Quellen und Nachweise

ORD-Eintrag
ord-564983da2cb248ba84f5fb347a8c730e
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156837B2

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