Hydrochloric Acid → (1S,2S)-1-N-Methyl-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

HRID 1750500Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750500
C[C:2]1[C:3]([NH:12][C@H:13]2[CH2:17][CH2:16][CH2:15][C@@H:14]2[NH:18]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[ClH:26].O1CCOC[CH2:28]1>CO>[ClH:26].[CH3:28][N:12]([C:3]1[CH:2]=[N:7][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:5][N:4]=1)[C@H:13]1[CH2:17][CH2:16][CH2:15][C@@H:14]1[NH2:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 118308261tert-Butyl N-[(1S,2S)-2-{[3-methyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate

Produkt 1

HCID 118308127(1S,2S)-1-N-Methyl-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl N-[(1S,2S)-2-{[3-methyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate (480 mg, 1.332 mmol) in methanol (5 ml) was added HCl in 1,4-dioxane (4 M, 3.33 ml, 13.32 mmol). The reaction was stirred at room temperature overnight and then concentrated in vacuo, azeotropically distilled with toluene to afford the title compound.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. distillationazeotropically distilled with toluene

Quellen und Nachweise

ORD-Eintrag
ord-e0a6fbbe63ad405995005a973b29e01b
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156829B2

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