Hydrochloric Acid → (1S,2S)-1-N-[3-Cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

HRID 1750568Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1750568
[CH:1]1([C:4]2[C:5]([NH:14][C@H:15]3[CH2:19][CH2:18][CH2:17][C@@H:16]3[NH:20]C(=O)OC(C)(C)C)=[N:6][CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=2)[CH2:3][CH2:2]1.[ClH:28]>O1CCOCC1>[ClH:28].[CH:1]1([C:4]2[C:5]([NH:14][C@H:15]3[CH2:19][CH2:18][CH2:17][C@@H:16]3[NH2:20])=[N:6][CH:7]=[C:8]([C:10]([F:12])([F:13])[F:11])[N:9]=2)[CH2:2][CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 118308262tert-Butyl N-[(1S,2S)-2-{[3-cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate

Produkt 1

HCID 118308108(1S,2S)-1-N-[3-Cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of tert-butyl N-[(1S,2S)-2-{[3-cyclopropyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]carbamate (1.54 g, 3.99 mmol) in 1,4-dioxane (14 ml) was added HCl in 1,4-dioxane (4M, 10 ml, 40 mmol). The reaction was stirred at room temperature for 20 hours and was then concentrated in vacuo and azeotropically distilled with toluene to afford the title compound.

Aufarbeitung

  1. concentrationwas then concentrated in vacuo
  2. distillationazeotropically distilled with toluene

Quellen und Nachweise

ORD-Eintrag
ord-de352cbc89984acdbab37a740644e4fd
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156829B2

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