5-Fluoro-2-(pyrimidin-2-yl)benzoic acid → 5-Fluoro-2-(pyrimidin-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]benzamide

Reaktionsgleichung

CC1N=C(C2C=CC=CC=2C([NH:11][C@H:12]2[CH2:16][CH2:15][CH2:14][C@@H:13]2[NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][N:19]=2)=O)ON=1.[F:32][C:33]1[CH:34]=[CH:35][C:36]([C:42]2[N:47]=[CH:46][CH:45]=[CH:44][N:43]=2)=[C:37]([CH:41]=1)[C:38]([OH:40])=O.Cl.FC(F)(F)C1C=CC(N[C@H]2CCC[C@@H]2N)=NC=1>>[F:32][C:33]1[CH:34]=[CH:35][C:36]([C:42]2[N:47]=[CH:46][CH:45]=[CH:44][N:43]=2)=[C:37]([CH:41]=1)[C:38]([NH:11][C@H:12]1[CH2:16][CH2:15][CH2:14][C@@H:13]1[NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:20][N:19]=1)=[O:40]