2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide → N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

HRID 17510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 17510
C([O:8][CH2:9][C:10]([NH:12][C:13]1[C:18]([C:19]#[N:20])=[C:17]([CH3:21])[C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:15]([F:28])[C:14]=1[OH:29])=[O:11])C1C=CC=CC=1>[C].[Pd].C(O)C>[C:19]([C:18]1[C:13]([NH:12][C:10](=[O:11])[CH2:9][OH:8])=[C:14]([OH:29])[C:15]([F:28])=[C:16]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:17]=1[CH3:21])#[N:20]

Komponenten

4

Edukt 1

HCID 866308382-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide

Produkt 1

HCID 86630863N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A catalyst 10%-palladium carbon (40.0 mg) was added to an ethanol (10 ml) solution of 2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide (I-89) (120 mg, 0.307 mmol), followed by stirring under hydrogen atmosphere at room temperature for 15 hours. After the reaction, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the entitled compound. Not purified, this was used in the next reaction as such.

Aufarbeitung

  1. customAfter the reaction
  2. customthe insoluble matter was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customto obtain the entitled compound
  5. customNot purified
  6. customthis was used in the next reaction as such

Quellen und Nachweise

ORD-Eintrag
ord-648b7b07cd4b472093af3e33c292ca65
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737166B2

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