Sodium Azide → 1-(Azidomethyl)-4-(trifluoromethyl)benzene

HRID 1752556Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1752556
[N-:1]=[N+:2]=[N-:3].[Na+].[F:5][C:6]([F:16])([F:15])[C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Br)=[CH:9][CH:8]=1>CS(C)=O.C(OCC)(=O)C>[N:1]([CH2:11][C:10]1[CH:9]=[CH:8][C:7]([C:6]([F:5])([F:15])[F:16])=[CH:14][CH:13]=1)=[N+:2]=[N-:3]

Komponenten

5

Edukt 2

HCID 33557Sodium AzideHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

Produkt 1

HCID 498459471-(Azidomethyl)-4-(trifluoromethyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Sodium azide (2.30 g, 35.4 mmol) was added to a solution of 4-(trifluoromethyl)benzyl bromide (4.26 g, 17.8 mmol) dissolved in dimethyl sulfoxide (15 mL) and stirred at ambient temperature overnight. The mixture was diluted with ethyl acetate, washed with water and brine, and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to afford the title compound. The crude product was used in the next step without further characterization.

Aufarbeitung

  1. washwashed with water and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationAfter filtration
  4. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8799b9f656294b06ad3fcd74eccbaab3
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09163007B2

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