Sodium Hydroxide → Disodium

HRID 1753777Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1753777
[OH-].[Na+:2].P([O-])([O-])([O-])=O.[Na+:8].[Na+].[Na+].[CH:11]1[C:16]([C:17]([NH:19][C@H:20]([C:26]([OH:28])=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[O:18])=[CH:15][CH:14]=[C:13]([NH:29][CH2:30][C:31]2[CH:32]=[N:33][C:34]3[N:40]=[C:39]([NH2:41])[N:38]=[C:37]([NH2:42])[C:35]=3[N:36]=2)[CH:12]=1>[Cl-].[Na+]>[Na:2][Na:8].[CH:15]1[C:16]([C:17]([NH:19][C@H:20]([C:26]([OH:28])=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[O:18])=[CH:11][CH:12]=[C:13]([NH:29][CH2:30][C:31]2[CH:32]=[N:33][C:34]3[N:40]=[C:39]([NH2:41])[N:38]=[C:37]([NH2:42])[C:35]=3[N:36]=2)[CH:14]=1

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 24243Trisodium Phosphate2×HCID 169371Aminopterin

Produkt 2

HCID 141233DisodiumHCID 169371Aminopterin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5234Sodium ChlorideLösungsmittel2×

Versuchsvorschrift

Clean glassware to be used with 2 M NaOH for 3-5 minutes and the rinse thoroughly with deionized water. Prepare a first saline buffer by adding 2.7017 grams of dibasic sodium phosphate, USP to 5 liters of 0.9% sodium chloride for injection, USP. Prepare a second saline buffer by adding 1.39 grams of monobasic sodium phosphate, USP to 1 liter of 0.9% sodium chloride for injection, USP. While stirring the first saline buffer solution, slowly add the second saline buffer solution until the final pH is 7.9-8.1. Record the final volume. Add sufficient aminopterin salt, preferably the disodium salt, to provide 0.4 mg/ml aminopterin (i.e. 2 mg aminopterin per 5 ml) and filter through a 0.2 micron membrane filter, desiccate by freeze drying to a solid powder, and package under sterile conditions in 10-ml vials that are sealed from the atmosphere. Resuspend with the appropriate amount of sterile water at the time of administration.

Aufarbeitung

  1. washthe rinse thoroughly with deionized water
  2. customPrepare a first saline buffer
  3. customPrepare a second saline buffer
  4. additionslowly add the second saline buffer solution until the final pH is 7.9-8.1

Quellen und Nachweise

ORD-Eintrag
ord-ebd48a58a0894629807364b83af83436
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09168256B2

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