Hydrochloric Acid → 1-(2-Chloro-6-hydroxyphenyl)ethan-1-one

HRID 1753965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1753965
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8]COC)[C:3]=1[C:12](=[O:14])[CH3:13].Cl>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:12](=[O:14])[CH3:13]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 669605601-[2-Chloro-6-(methoxymethoxy)phenyl]ethanone

Produkt 1

HCID 5934151-(2-Chloro-6-hydroxyphenyl)ethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

To a solution of 1-(2-chloro-6-(methoxymethoxy)phenyl)ethanone (38 g, 177.03 mmol, 1.00 equiv) in THF (380 mL) was added HCl (aq. 35 g, 2.00 equiv, 36%). The resulting mixture was allowed to react, with stirring, for 3 h at 65° C. The resulting mixture was extracted with ethyl acetate. The organic phase was separated, dried and concentrated under vacuum to give the crude title compound.

Aufarbeitung

  1. customto react
  2. extractionThe resulting mixture was extracted with ethyl acetate
  3. customThe organic phase was separated
  4. customdried
  5. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-03868c8c1c2a46798ba082f6f08f4fe3
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09168248B2

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