Sodium Hydroxide → 4-((3-(Trifluoromethoxy)phenyl)sulfonyl)aniline

HRID 1754113Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1754113
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:5]=[C:6]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(=O)C)=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1.[OH-].[Na+]>CCO>[F:24][C:2]([F:1])([F:23])[O:3][C:4]1[CH:5]=[C:6]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 70978998N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acetamide

Produkt 1

HCID 891567704-((3-(Trifluoromethoxy)phenyl)sulfonyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acetamide (104 mg, 0.29 mmol) in EtOH (8 mL) is added NaOH (10 M in water, 0.6 mL, 6 mmol). The mixture is heated at 80° C. for 4 h and the solvent is evaporated. The residue is partitioned between EtOAc (15 mL) and brine (10 mL) and the layers are separated. The aqueous layer is extracted with EtOAc (10 mL) and the combined extracts are dried (Na2SO4) and evaporated. The white solid obtained (86 mg, 93%) is used to the next step without further purification.

Aufarbeitung

  1. customthe solvent is evaporated
  2. customThe residue is partitioned between EtOAc (15 mL) and brine (10 mL)
  3. customthe layers are separated
  4. extractionThe aqueous layer is extracted with EtOAc (10 mL)
  5. dry with materialthe combined extracts are dried (Na2SO4)
  6. customevaporated
  7. customThe white solid obtained (86 mg, 93%)
  8. customis used to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c28c4b314c3f439fbf8aa6f320d4b608
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09169209B2

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