Sodium Hydroxide → 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl-

HRID 1754494Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1754494
COC([N:5]1[C:9]2=[N:10][C:11]([Cl:14])=[CH:12][CH:13]=[C:8]2[CH:7]=[C:6]1[CH3:15])=O.[OH-].[Na+]>CO>[Cl:14][C:11]1[N:10]=[C:9]2[NH:5][C:6]([CH3:15])=[CH:7][C:8]2=[CH:13][CH:12]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 73013581HCID 73013581, Verbindung

Produkt 1

HCID 210617341H-Pyrrolo[2,3-b]pyridine, 6-chloro-2-Methyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6-Chloro-2-methyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid methyl ester (0.225 g, 1 mmol) is dissolved in methanol (30 ml) and 1M NaOH (10 ml) and stirred at room temperature overnight. The methanol is removed in vacuo and the resulting white suspension is extracted with chloroform (3×20 ml), dried (MgS04) and concentrated in vacuo to yield a white powder which is dried under high vacuum to yield the titled product. (MH+167).

Aufarbeitung

  1. customThe methanol is removed in vacuo
  2. extractionthe resulting white suspension is extracted with chloroform (3×20 ml)
  3. customdried (MgS04)
  4. concentrationconcentrated in vacuo
  5. customto yield a white powder which
  6. customis dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-60d331f27706454cbd8ee037714249b7
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09169251B2

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