Allyl bromide → N-allyl-D-alanine t-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:10])[C@@H:7]([CH3:9])[NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:11](Br)[CH:12]=[CH2:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:10])[C@@H:7]([CH3:9])[NH:8][CH2:13][CH:12]=[CH2:11])([CH3:4])([CH3:3])[CH3:2]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
D-Alanine t-butylester (68) is treated with one equivalent allyl bromide and one equivalent of triethylamine in toluene under reflux. The solvent is evaporated and the product is purified by flash chromatography on silica gel to give (69).
Aufarbeitung
- temperatureunder reflux
- customThe solvent is evaporated
- customthe product is purified by flash chromatography on silica gel
Quellen und Nachweise
- ORD-Eintrag
- ord-48efffad11d94dafa55ea06d132ab9b7
- Quelldatensatz
- uspto-grants-1995_08
- Patentnummer
- US05438118
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