2-Chloro-4'-fluoroacetophenone → HCID 23207150, Verbindung

HRID 1756078Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1756078
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]=1[CH3:13])#[N:2].[F:14][C:15]1[CH:24]=[CH:23][C:18]([C:19](=[O:22])[CH2:20][Cl:21])=[CH:17][CH:16]=1>C(#N)C>[ClH:21].[C:1]([CH2:3][C:4]1[C:12]2[C:7]([N:8]([CH2:20][C:19]([C:18]3[CH:23]=[CH:24][C:15]([F:14])=[CH:16][CH:17]=3)=[O:22])[CH:9]=[CH:10][CH:11]=2)=[N:6][C:5]=1[CH3:13])#[N:2]

Komponenten

4

Edukt 2

HCID 1202482-Chloro-4'-fluoroacetophenoneHCID 19916764(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile

Produkt 1

HCID 23207150HCID 23207150, VerbindungAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 7 5 mg (0.44 mmol) of 3-cyanomethyl-2-methyl-pyrrolo [2,3 -b]pyridine and 99 mg(0.57 mmol) of 4-fluorophenacyl chloride in 1 ml acetonitrile was refluxed for 48 h. The solvent was evaporated and the residue was treated with 0.4 ml acetonitrile. After filtration the solid was treated with 0,3 ml methanol and 0,4 ml acetonitrile to give 75 mg (55% ) of the title compound.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionthe residue was treated with 0.4 ml acetonitrile
  3. filtrationAfter filtration the solid
  4. additionwas treated with 0,3 ml methanol and 0,4 ml acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-5bc533e53c32447ba8b1bceb44421817
Quelldatensatz
uspto-grants-1995_08
Patentnummer
US05439917

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