Potassium Fluoride → Ethyl 3-(3thienyl)phenoxyacetate

HRID 1756155Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1756155
Br[C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8].C([Sn](CCCC)(CCCC)[C:20]1[CH:24]=[CH:23][S:22][CH:21]=1)CCC.[F-].[K+]>C1(C)C(C)=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[S:22]1[CH:23]=[CH:24][C:20]([C:2]2[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=2)[O:5][CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:21]1

Komponenten

6

Edukt 3

HCID 522689Potassium FluorideHCID 5197439Ethyl 2-(3-bromophenoxy)acetateHCID 10959689Stannane, tributyl-3-thienyl-

Produkt 1

HCID 19916940Ethyl 3-(3thienyl)phenoxyacetateAusbeute 64,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

2.6 g of the resulting ether compound, 5.3 g of tri-n-butyl(3-thienyl)tin and 20 mg of tetrakis(triphenylphosphine)palladium were dissolved in 10 ml of xylene, and the mixture was refluxed for 5.5 hours. A 25% aqueous solution of potassium fluoride was added to the solution, and then the precipitate was removed by filtration. The organic layer separated was worked up in a customary manner, and the product was purified by silica gel column chromatography [hexane/ethyl acetate=20/1→15/1] to give 1.7 g of ethyl 3-(3thienyl)phenoxyacetate as a white powder.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 5.5 hours
  2. customthe precipitate was removed by filtration
  3. customThe organic layer separated
  4. customthe product was purified by silica gel column chromatography [hexane/ethyl acetate=20/1→15/1]

Quellen und Nachweise

ORD-Eintrag
ord-f7b35241cf3940bdb8f07315907b7130
Quelldatensatz
uspto-grants-1995_08
Patentnummer
US05439932

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