Isopropanol → 4-Cyclopropylmethoxy-2-chloromethylpyridine hydrochloride
Reaktionsgleichung
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([CH2:12]O)[CH:7]=2)[CH2:3][CH2:2]1.O=S(Cl)[Cl:16].C(O)(C)C>C(Cl)Cl>[ClH:16].[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][Cl:16])[CH:7]=2)[CH2:3][CH2:2]1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
4-cyclopropylmethoxy-2-hydroxymethylpyridine (93% pure) (0.9 g 0.0046 mol) was dissolved in methylene chloride (10 ml) and cooled to 0° C. SOCl2 (0.5 ml, 0.0069 mol) in methylene chloride (5 ml) was added dropwise at 0° C. and the reaction mixture was stirred 15 min at room temperature. Isopropanol (0.5 ml) was added and the mixture was evaporated giving the desired product (0.68 g, 78%). NMR data is given below.
Aufarbeitung
- customthe mixture was evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-4612185971b94cdb92acb96ea0b8fe30
- Quelldatensatz
- uspto-grants-1995_08
- Patentnummer
- US05441968
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