Acetone → HCID 178473693, Verbindung

HRID 1758303Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1758303
[SH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:13][C:14]([CH3:16])=[O:15]>>[C:14]([CH2:16][S:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1)(=[O:15])[CH3:13]

Komponenten

4

Edukt 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 178527994HCID 178527994, Verbindung

Produkt 1

HCID 178473693HCID 178473693, Verbindung

Versuchsvorschrift

5-Mercapto-1,2,3,4-tetrazole (1 g), potassium carbonate (2 g) and β-chloroacetone (1.4 g) are added to acetone (50 ml) and the solution is refluxed with stirring for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure and the residue is dissolved in chloroform. Insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel column chromatography (Kieselgel 60, eluant: benzene-ether (10:1) to obtain 5-acetylmethylthio-1,2,3,4-tetrazole (0.4 g) as colorless liquid.

Aufarbeitung

  1. temperaturethe solution is refluxed
  2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
  3. dissolutionthe residue is dissolved in chloroform
  4. filtrationInsolubles are filtered off
  5. concentrationthe filtrate is concentrated under reduced pressure
  6. customThe residue is purified by silica gel column chromatography (Kieselgel 60, eluant

Quellen und Nachweise

ORD-Eintrag
ord-c7e52f44d55c4e29bfb4f06df1b9487d
Quelldatensatz
uspto-grants-1983_02
Patentnummer
US04372953

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