Dimethylamine → 4-Dimethylaminomethyl-2-hydroxymethylthiazole
Reaktionsgleichung
CNC.BrC1SC=C(CCl)N=1.Br[C:13]1[S:14][CH:15]=[C:16]([CH2:18][N:19]([CH3:21])[CH3:20])[N:17]=1.[CH2:22]=[O:23]>C(O)C>[CH3:20][N:19]([CH2:18][C:16]1[N:17]=[C:13]([CH2:22][OH:23])[S:14][CH:15]=1)[CH3:21]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
An ethanol solution of dimethylamine is reacted with 2-bromo-4-chloromethylthiazole, prepared according to reference (4) above, and the resultant 2-bromo-4-dimethylaminomethylthiazole is treated with a strong base and formaldehyde according to the general procedure described in Acta Chem. Scand., 20, 2649 (1966), to give the desired 4-dimethylaminomethyl-2-hydroxymethylthiazole.
Aufarbeitung
- customprepared
Quellen und Nachweise
- ORD-Eintrag
- ord-6a86ecbfec7d46c1a26c357cf170365f
- Quelldatensatz
- uspto-grants-1983_02
- Patentnummer
- US04374248
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