2-Amino-5-(trifluoromethyl)pyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1758926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1758926
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([N:17]=[C:18]=[O:19])=[O:16]>>[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([NH:17][C:18]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N:7]=1)=[O:19])=[O:16]

Komponenten

3

Edukt 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 130517312-Chloro-6-fluorobenzoyl isocyanate

Produkt 1

HCID 205331381-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

Versuchsvorschrift

A portion of 5-trifluoromethyl-2-aminopyridine is reacted with 2-chloro-6-fluorobenzoyl isocyanate as described in Example 1. The reaction mixture is evaporated under vacuum and the product is recrystallized to obtain the product named above.

Aufarbeitung

  1. customThe reaction mixture is evaporated under vacuum
  2. customthe product is recrystallized
  3. customto obtain the product

Quellen und Nachweise

ORD-Eintrag
ord-b8eb3f1f637c4e79a5ec9277707eb4d3
Quelldatensatz
uspto-grants-1982_07
Patentnummer
US04338321

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