Phenylethanolamine → N-[2-(4-(3-Carbomethoxypropoxy)phenyl)-1-methylethyl]-2-hydroxy-2-phenylethanamine
Reaktionsgleichung
[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16](=O)[CH3:17])=[CH:11][CH:10]=1)([O:3][CH3:4])=[O:2].[OH:19][CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:21][NH2:22]>>[C:1]([CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([NH:22][CH2:21][CH:20]([OH:19])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH3:17])=[CH:11][CH:10]=1)([O:3][CH3:4])=[O:2]Komponenten
3
Versuchsvorschrift
The compound was prepared as in Example 5 from 1-(4-(3-carbomethoxypropoxy)phenyl] propan-2-one (6.0 g) and 2-hydroxy-2-phenyl ethanamine (3.29 g) and crystallised from hexane m.p. 60°-76° as a 1:1 mixture of diastereoisomers.
Aufarbeitung
- customcrystallised from hexane m.p. 60°-76° as a 1:1 mixture of diastereoisomers