1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

HRID 1759374

Reaktionsgleichung

Reaktionsgleichung von HRID 1759374
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]CC(=O)C(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:34][C:35]1([CH3:42])[CH2:40][NH:39][C:38](=[S:41])[NH:37][CH2:36]1>CC(C)=O>[BrH:17].[C:11]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2([OH:10])[N:39]3[CH2:40][C:35]([CH3:42])([CH3:34])[CH2:36][N:37]=[C:38]3[S:41][CH2:9]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

5

Edukt 3

HCID 699071,1-DiphenylacetoneHCID 27946353-Bromo-1,1-diphenylacetone2×HCID 38664875,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol

Produkt 1

HCID 155712123-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone as described in Example 22. This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 1.0 g. of tetrahydro-5,5-dimethyl-2(1H)-pyrimidinethione in 50 ml. of acetone. The mixture is allowed to stand at room temperature for 24 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 259°-261° C.

Aufarbeitung

  1. filtrationthe resulting solid is collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-74b9700bce794469a10ff051d82ec604
Quelldatensatz
uspto-grants-1982_07
Patentnummer
US04340734

Verknüpfte Notizen

Wird geladen…