Ammonium Chloride → 3-amino-4-chlorobenzophenone

HRID 1759386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1759386
[Cl-].[NH4+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:6][C:5]=1[N+:18]([O-])=O>[Fe].CC1C=CC=CC=1>[NH2:18][C:5]1[CH:6]=[C:7]([C:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[CH:8]=[CH:9][C:4]=1[Cl:3]

Komponenten

5

Edukt 2

HCID 25517Ammonium ChlorideHCID 417434-Chloro-3-nitrobenzophenone

Produkt 1

HCID 107995483-amino-4-chlorobenzophenone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

To a stirred and refluxing mixture of 11.2 parts of iron, 100 parts of ammonium chloride solution 0.8 N and 20 parts of methylbenzene are added 10.5 parts of (4-chloro-3-nitrophenyl)phenylmethanone and the whole is further stirred at reflux temperature for one hour. Methylbenzene (80 parts) is added and the whole is filtered over Hyflo. The organic layer is separated, dried, filtered and evaporated. The residue is washed with cyclohexane, yielding 8.4 parts of (3-amino-4-chlorophenyl)phenylmethanone; mp. 91.9° C.

Aufarbeitung

  1. temperaturerefluxing
  2. stirringthe whole is further stirred
  3. temperatureat reflux temperature for one hour
  4. filtrationthe whole is filtered over Hyflo
  5. customThe organic layer is separated
  6. customdried
  7. filtrationfiltered
  8. customevaporated
  9. washThe residue is washed with cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-9e37156dceda471ea11ca19b2137ca48
Quelldatensatz
uspto-grants-1982_07
Patentnummer
US04340738

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