Sodium Hydroxide → Benzyl D-valinate

HRID 1760774Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1760774
[OH-].[Na+].FC(F)(F)C(O)=O.[CH2:10]([O:17][C:18](=[O:24])[C@@H:19]([CH:21]([CH3:23])[CH3:22])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[CH2:10]([O:17][C:18](=[O:24])[C@@H:19]([CH:21]([CH3:22])[CH3:23])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 69764497d-Valine benzyl ester trifluoroacetic acid salt

Produkt 1

HCID 7350007Benzyl D-valinateAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1 N Sodium hydroxide (80 mL) was added to a solution of D-valine benzyl ester trifluoroacetic acid salt (10 g, 31.1 mmol) in methylene chloride (80 mL) and the reaction mixture was stirred until all the starting material was converted to the free amine. The organic phase was collected and washed with brine, dried over magnesium sulfate, and concentrated to give D-valine benzyl ester (5.35 g) as a clear oil.

Aufarbeitung

  1. customThe organic phase was collected
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-e06787d19cec44b5bc528458538a55f9
Quelldatensatz
uspto-grants-2005_01
Patentnummer
US06844366B2

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