Ethyl 2-chloroacetoacetate → HCID 14500742, Verbindung

HRID 1761558Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1761558
[N:1]1([C:7]([NH:9][NH2:10])=S)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:11][CH:12]([C:18]([CH3:20])=O)[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[ClH:11].[CH3:20][C:18]1[NH:10][N:9]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[C:12]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Komponenten

4

Edukt 2

HCID 11858Ethyl 2-chloroacetoacetateHCID 4860905morpholine-4-carbothiohydrazide

Produkt 1

HCID 14500742HCID 14500742, VerbindungAusbeute 51,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A stirred slurry of 6.3 g (0.039 mole) of 4-morpholinecarbothioic acid hydrazide in 75 mL of absolute ethanol under nitrogen atmosphere was treated with 6.43 g (0.039 mole) of ethyl 2-chloroacetoacetate and the exothermic reaction mixture stirred at ambient temperature for 18 hr. The major portion of reaction mixture solids were dissolved by heating to reflux, the sulfur residue removed by filtration and the filtrate concentrated in vacuo to a solid, which was crystallized from 2-propyl alcohol to yield 5.5 g of white crystalline needles, mp 165°-173° C., as the hydrochloride salt.

Aufarbeitung

  1. customThe major portion of reaction mixture solids
  2. dissolutionwere dissolved
  3. temperatureby heating
  4. temperatureto reflux
  5. customthe sulfur residue removed by filtration
  6. concentrationthe filtrate concentrated in vacuo to a solid, which
  7. customwas crystallized from 2-propyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-d9a4da3eacb24090900e54afef2db407
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04826866

Notizen zur Reaktion

Wird geladen…