N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide → 5-Chloro-4-fluoro-2-nitroaniline

HRID 1761642Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1761642
[Cl:1][C:2]1[CH:3]=[C:4]([NH:12]C(=O)C)[C:5]([N+:9]([O-:11])=[O:10])=[CH:6][C:7]=1[F:8]>Cl.C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([N+:9]([O-:11])=[O:10])=[CH:6][C:7]=1[F:8])[NH2:12]

Komponenten

4

Edukt 1

HCID 2773811N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide

Produkt 1

HCID 5178355-Chloro-4-fluoro-2-nitroanilineAusbeute 101,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of N-(3-chloro-4-fluoro-6-nitrophenyl)acetamide (30 g) in concentrated hydrochloric acid (50 ml) and ethanol (200 ml) was refluxed for 2.5 hours. To the reaction mixture was added ice water (300 ml) and the resulting precipitate was collected by filtration, washed with water and dried to give the title compound (24.9 g) as yellow needles, mp 149.5°-150° C.

Aufarbeitung

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5910cdfdf8d448a4a349dea5664d92e6
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04826982

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