Aluminum(III) Chloride → 2,3-Dichloro-4-hydroxy-N-n-butylaniline

HRID 1761667

Reaktionsgleichung

Reaktionsgleichung von HRID 1761667
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([O:14]C)[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C(Cl)Cl>[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([OH:14])[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

4

Edukt 2

HCID 6451240Aluminum(III) ChlorideHCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

Produkt 1

HCID 198144102,3-Dichloro-4-hydroxy-N-n-butylaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 65911,1,2,2-TetrachloroethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 2,3-dichloro-4-methoxy-N-n-butylaniline (8.5 g) in 1,1,2,2-tetrachloroethane (80 ml) is added anhydrous aluminium chloride (8.5 g), and the mixture is refluxed for about 40 hours. The resulting mixture is poured into ice/water (about 500 ml), and the precipitated material is extracted twice with methylene chloride. The combined extracts are dried and evaporated in vacuo to give the title compound as a heavy oil.

Aufarbeitung

  1. temperaturethe mixture is refluxed for about 40 hours
  2. extractionthe precipitated material is extracted twice with methylene chloride
  3. customThe combined extracts are dried
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8388fbe10957459ba1e0699610d265f6
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04826987

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