Ammonia → HCID 21242407, Verbindung

Reaktionsgleichung

[CH2:1]([N:4]([C:10]([O:12][CH3:13])=[O:11])[CH2:5][C:6](OC)=O)[C:2]#[CH:3].[NH3:14].C[OH:16]>>[CH2:1]([N:4]([C:10]([O:12][CH3:13])=[O:11])[C:5](=[O:16])[CH2:6][NH2:14])[C:2]#[CH:3]

Komponenten

Edukt 3

HCID 222Ammonia

HCID 887Methanol

HCID 14580243HCID 14580243, Verbindung

Produkt 1

HCID 21242407HCID 21242407, Verbindung

Versuchsvorschrift

3.9 g of methyl N-propargyl-N-methoxycarbonylglycinate were added to the mixture of 100 ml of 28% aqueous ammonia and 10 ml of methanol and stirred for 10 hours at room temperature. Then the solvent was evaporated off from the reaction mixture. The residue was chromatograhed on silica gel to obtain 3.0 g of N-propargyl-N-methoxycarbonylglycinamide (melting point: 77°-80° C.).