Sodium Bicarbonate → Methyl 2-(4-aminophenyl)benzofuran-7-carboxylate

HRID 1761909Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1761909
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]3[C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]3[C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 14229713Methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate

Produkt 1

HCID 14229714Methyl 2-(4-aminophenyl)benzofuran-7-carboxylateAusbeute 93,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of 3.1 g of methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate, 11.7 g of stannous chloride dihydrate and 100 ml of ethyl acetate is heated at 70° C. for 1 hour. After cooling, the reaction mixture is alkalized with an aqueous sodium bicarbonate solution and extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent to give 2.6 g of methyl 2-(4-aminophenyl)benzofuran-7-carboxylate as yellow crystals.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with water
  4. customdried
  5. customevaporated
  6. customto remove solvent

Quellen und Nachweise

ORD-Eintrag
ord-a5c7623183c14b62b81be3b37ab22eab
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04829067

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