Triethylamine → 5-Hydroxy-4,6,7-trifluoro-3-(pentafluorobenzylidene)phthalide

HRID 1762312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1762312
[F:1][C:2]1[C:10]([OH:11])=[C:9]([F:12])[C:8]([F:13])=[C:4]([C:5]([OH:7])=O)[C:3]=1[C:14]([OH:16])=O.FC1C(F)=C(F)C(F)=C2C(=O)OC(=O)C=12.[F:32][C:33]1[C:38]([CH2:39]C(O)=O)=[C:37]([F:43])[C:36]([F:44])=[C:35]([F:45])[C:34]=1[F:46].C(N(CC)CC)C>C(N(CC)CC)C.C(OC(=O)C)(=O)C>[OH:11][C:10]1[C:2]([F:1])=[C:3]2[C:4](=[C:8]([F:13])[C:9]=1[F:12])[C:5](=[O:7])[O:16][C:14]2=[CH:39][C:38]1[C:37]([F:43])=[C:36]([F:44])[C:35]([F:45])=[C:34]([F:46])[C:33]=1[F:32]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 69545Tetrafluorophthalic anhydrideHCID 69553(Pentafluorophenyl)acetic acidHCID 101985873,4,6-Trifluoro-5-hydroxyphthalic acid

Produkt 1

HCID 736756405-Hydroxy-4,6,7-trifluoro-3-(pentafluorobenzylidene)phthalide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21881581Acetic anhydride triethylamineLösungsmittel

Versuchsvorschrift

A process for preparing 3,5,6-trifluoro-4-hydroxyphthalic acid used here as the starting material is described in Osadchii, S. A., Bakahash, V. A.; Zh. Org. Khim., Vol. 6 (8), p. 1636 (1970) (Chemical Abstract, 73, 109544p). According to this litrature, when tetrafluorophthalic anhydride and pentafluorophenylacetic acid are reacted in triethylamine-acetic anhydride, a triethylamine salt of 5-hydroxy-4,6,7-trifluoro-3-(pentafluorobenzylidene)phthalide is obtained. And, by treatment of the by-products of this reaction, 3,5,6-trifluoro-4-hydroxyphthalic acid is obtained.

Quellen und Nachweise

ORD-Eintrag
ord-ed6bc3cba3af4f3bb2061a3dcb78b3a3
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04831190

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