Benzyl Bromide → 1-Benzyloxy-3-methyl-2-nitrobenzene

HRID 1762938

Reaktionsgleichung

Reaktionsgleichung von HRID 1762938
[CH3:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C)C=O>[CH2:18]([O:8][C:4]1[C:3]([N+:9]([O-:11])=[O:10])=[C:2]([CH3:1])[CH:7]=[CH:6][CH:5]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

5

Edukt 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 210263-Methyl-2-nitrophenol

Produkt 1

HCID 33441871-Benzyloxy-3-methyl-2-nitrobenzeneAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 15.3 g of 3-methyl-2-nitrophenol in 150 ml of dimethylformamide is combined with 28 g of potassium carbonate and 34.2 g of benzyl bromide, and the mixture is stirred for 3 hours at 70°-80° C. Then the inorganic salts are vacuum-filtered, washed with dichloromethane, and the filtrate evaporated under vacuum. The residue is distilled in a bulb tube at a bath temperature of 120° C. and at 0.01 torr, thus obtaining 23.2 g of 3-benzyloxy-2-nitrotoluene as an oil.

Aufarbeitung

  1. filtrationThen the inorganic salts are vacuum-filtered
  2. washwashed with dichloromethane
  3. customthe filtrate evaporated under vacuum
  4. distillationThe residue is distilled in a bulb tube at a bath temperature of 120° C.

Quellen und Nachweise

ORD-Eintrag
ord-11eb59d2eae542c8bfb4216b0345dc47
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04835175

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