Benzyl Chloride → N-Benzylcrotonamide

HRID 1763092

Reaktionsgleichung

Reaktionsgleichung von HRID 1763092
[C:1]([NH2:6])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:7](Cl)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CN(C)C=O>[CH2:7]([NH:6][C:1](=[O:5])/[CH:2]=[CH:3]/[CH3:4])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 7503Benzyl ChlorideHCID 53544872-Butenamide

Produkt 1

HCID 2313079N-BenzylcrotonamideAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 200 ml of N,N-dimethylformamide, were added 17 g of crotonamide, 105 g of LEVATIT MP-500, which was also used in Example 68, and 32 g of benzylchloride. They were reacted at 50° C. for 4 hours with stirring. After the reaction, the reaction solution was treated in the same manner as in Example 69, the resulting distillation residue was recrystallized from benzine, and 25 of N-benzylcrotonamide having a melting point of 112.5°-113.6° C. was obtained (yield: 71%).

Aufarbeitung

  1. customThey were reacted at 50° C. for 4 hours
  2. customAfter the reaction
  3. additionthe reaction solution was treated in the same manner as in Example 69
  4. distillationthe resulting distillation residue
  5. customwas recrystallized from benzine, and 25 of N-benzylcrotonamide having a melting point of 112.5°-113.6° C.
  6. customwas obtained (yield: 71%)

Quellen und Nachweise

ORD-Eintrag
ord-0d5f89ffa64b4db3a7c5df88b628343f
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04835312

Verknüpfte Notizen

Wird geladen…