Triethylamine → HCID 13233034, Verbindung

HRID 1763187Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763187
Cl.[C:2]([S:6][CH2:7][NH:8][CH3:9])([CH3:5])([CH3:4])[CH3:3].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1.C(N(CC)CC)C>C(#N)C>[CH3:9][N:8]([CH2:7][S:6][C:2]([CH3:5])([CH3:4])[CH3:3])[C:19]([NH:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([C:11]([F:10])([F:21])[F:22])[CH:13]=1)=[O:20]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 20309108N-(tert.-butylthiomethyl)-N-methyl amine hydrochloride

Produkt 1

HCID 13233034HCID 13233034, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Two grams of the product of Example I (0.0118 mole), 2.2 g. (0.0118 mole) of 3-trifluoromethylphenylisocyanate, and 100 ml. of acetonitrile are combined in a 250 ml. Erlenmeyer flask. The mixture is magnetically stirred, and 1.9 g. (0.0118 mole) of triethylamine are then added. The resulting mixture is stirred at room temperature for one hour and then poured into 300 ml. of ice water. The crystalline product is collected by filtration and dried to yield 2.0 g. (53% of theory) of the title compound, mp = 96°-99° C. Structure is confirmed by IR and NMR.

Aufarbeitung

  1. stirringThe resulting mixture is stirred at room temperature for one hour
  2. additionpoured into 300 ml
  3. filtrationThe crystalline product is collected by filtration
  4. customdried
  5. customto yield 2.0 g

Quellen und Nachweise

ORD-Eintrag
ord-a6aadf5ed0a140938581a74509fa2f68
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04111682

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