Triethylamine → 5-(4-Fluorobenzoyloxy)-3-methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-pyrazole

HRID 1763560Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763560
[CH3:1][C:2]1[NH:3][N:4]([CH:14]([CH3:23])[C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.[F:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1>O1CCOCC1>[F:31][C:32]1[CH:40]=[CH:39][C:35]([C:36]([O:13][C:5]2[N:4]([CH:14]([CH3:23])[C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=3)[N:3]=[C:2]([CH3:1])[C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:37])=[CH:34][CH:33]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 678794-Fluorobenzoyl chlorideHCID 203358943-Methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-5-pyrazolone

Produkt 1

HCID 203358595-(4-Fluorobenzoyloxy)-3-methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

0.1 mol (34.7 g) of 3-methyl-4-phenyl-1-(α-methyl-3,4-dichlorobenzyl)-5-pyrazolone was dissolved in 300 ml of absolute dioxane. After adding 15 ml of triethylamine, 0.11 mol (17 g) of p-fluorobenzoyl chloride in dioxane was added dropwise. After heating for several hours under reflux, the reaction batch was worked up as follows.

Aufarbeitung

  1. additionwas added dropwise
  2. temperatureAfter heating for several hours
  3. temperatureunder reflux

Quellen und Nachweise

ORD-Eintrag
ord-dd297b95e2ab4610a6ffe85fbfa5bfdf
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04112109

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